Comparison of the viscoelastic properties of human abdominal and breast adipose tissue and its incidence on breast reconstruction surgery. A pilot study

Abstract

Background: Breast cancer is the leading malignant tumor in women in the world. Reconstruction after mastectomy plays a key role in the physical and psychological recuperation, being the abdominal skin and adipose tissue the best current option for the DIEP surgery. The aim of the surgery is to obtain a reconstructed breast which looks and behaves naturally. Therefore, it would be useful to characterize the mechanical behaviour of the adipose tissue in the abdomen and breast to compare their mechanical properties, also investigating possible regional differences. Methods: Experimental tests have been carried out in breast and abdominal adipose tissue samples, obtaining their viscoelastic properties. The specimens have been subjected to uniaxial compression relaxation tests and a mechanical behaviour model has been fitted to the experimental curves. Afterwards, statistical analyses have been used to detect differences between different individuals' abdominal fat tissue and finally between different areas of the same individual's breast and abdominal adipose tissue. Findings: Several conclusions could be extracted from the results: 1) inter-individual differences may exist in the abdominal adipose tissue; 2) the breast fat could be regarded as a unique tissue from the mechanical point of view; 3) significant differences were detected between the superficial breast and all the locations of the abdomen, except for the superficial lateral one and 4) the mechanical properties of the abdominal adipose tissue seem to change with the depth. These conclusions can be of great value for DIEP surgeries and other surgeries in which the adipose tissue is involved.Ministerio de Economía y Competitividad DPI2011-2808