Gene expression regulation is an intricate,
dynamic phenomenon essential for all biolog ical functions. The necessary instructions for
gen expression are encoded in cis-regulatory
elements that work together and interact
with the RNA polymerase to confer specific
spatial and temporal patterns of transcrip tion. Therefore, the identification of these el ements is currently an active area of research
in computational analysis of regulatory se quences. However, the problem is difficult
since the combinatorial interactions between
the regulating factors can be very complex.
Here we present a web server, Cis-cop, that
identifies cis-regulatory modules given a set
of transcription factor binding sites and, ad ditionally, also RNA pol sites for a group of
genes
