The impacts of climate change and human activities on vegetation dynamics have attracted wide attention, especially in sensitive and vulnerable areas such as the Qingzang Plateau of China. In this region, a series of ecological restoration projects have been launched while the effectiveness of these projects requires evaluation and further improvements. Remote sensing with high temporal resolution and spatial coverage is an effective way for the vegetation dynamics research in this region. In this study, the spatial and temporal distribution of climate factors and vegetation coverage as well as the influencing factors such as air temperature, precipitation, land use, slope, slope direction, soil and altitude were analyzed. The geographical detector was used to analyze the influence of climate factors on vegetation coverage and the interaction among factors in different eco-geographical regions. The results showed that: 1) the average values from the 20 years of normalized difference vegetation index (NDVI) decreased gradually from southeast (> 0.61) to northwest (0.12). The overall average of NDVI increased 0.02 per year from 1998 to 2018 and the impact factors varied among different eco-geographical regions; 2) some controlling factors showed nonlinear enhancement such as altitude and slope; 3) land use was an important factor affecting the distribution of vegetation especially in humid, semi-arid and arid areas, but the impacts of elevation and temperature were stronger than land use types in semi-humid and humid areas. The design and construction of ecological protection and restoration projects on the Qingzang Plateau required scientific and detailed demonstration as well as monitoring and evaluation. In addition, new tools and theories were also needed in the selection of ecosystem restoration strategies. Based on the findings, this study also provides suggestions for the sustainable ecological restoration on the Qingzang Plateau
