Vivre au milieu des livres

Abstract

Que pèse la somme de nos lectures dans ce temps suspendu, et souvent déchiré, qui précède la décision ? Une bibliothèque n’enferme pas un répertoire de cas, auxquels nous pourrions tout uniment rapporter notre situation présente pour découvrir ce que nous avons à faire. Si les livres devaient nous rendre plus sages, ou mieux aptes à guider notre existence, le Dalaï Lama serait professeur de littérature. Et pourtant : si nous continuons à lire et à accumuler les volumes autour de nous, c’est bien que les livres nous aident à vivre à leur façon, que nos lectures ne restent pas sans effets sur la vie que nous menons. […]]]> fre https://serval.unil.ch/resource/serval:BIB_56947888885D.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_56947888885D7 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_56947888885D7 info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_5694E7648F91 2022-10-01T01:20:16Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_5694E7648F91 The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. info:doi:10.1097/SHK.0000000000000963 info:eu-repo/semantics/altIdentifier/doi/10.1097/SHK.0000000000000963 info:eu-repo/semantics/altIdentifier/pmid/29757923 Khan, A.I. Kapoor, A. Chen, J. Martin, L. Rogazzo, M. Mercier, T. Decosterd, L. Collino, M. Thiemermann, C. info:eu-repo/semantics/article article 2018-06 Shock, vol. 49, no. 6, pp. 675-681 info:eu-repo/semantics/altIdentifier/eissn/1540-0514 urn:issn:1073-2322 <![CDATA[Ischemic heart disease remains the leading cause of morbidity and mortality in the Western world. Artesunate is the WHO-recommended drug of choice for complicated malaria (with organ failure). The administration of high doses of artesunate is safe in healthy volunteers (up to 8 mg/kg i.v.) and patients with severe malaria (2.4 mg/kg i.v.). We investigated the effects of artesunate (1 mg/kg) or its active metabolite dihydroartemisinin (DHA; 0.1 mg/kg) in a model of transient myocardial ischemia/reperfusion (I/R) and evaluated the mechanism of action of the observed cardioprotective effects of artesunate and DHA. We report here for the first time that the administration of artesunate at the onset of reperfusion attenuates the myocardial injury associated with I/R. The observed beneficial effects of artesunate are associated with activation of the PI3K/Akt/ERK 1/2 (RISK) pathway, activation of endothelial nitric oxide synthase, inhibition of glycogen synthase kinase-3β, inhibition of nuclear factor kappa B, and activation of the STAT3 (SAFE) pathway. In conclusion, as artesunate has an excellent safety profile, the above data should stimulate clinical trials in patients with acute coronary syndromes