Biodegradable piezoelectrics represent an intriguing category of electroactive materials combining the mechanical-electrical coupling characteristics with a unique biodegradable feature that eliminates unnecessary materials retention and minimize associated infection risks. Here, we review the piezoelectric properties of representative organic biodegradable piezoelectric materials including amino acids, peptides, proteins, synthetic polymers and polysaccharides. Strategies to promote the piezoelectric activity are summarized, and recent progress in the utilization of biodegradable piezoelectric materials for bioelectronics is discussed, with perspectives and challenges provided at the end to enlighten possible future directions