La schizophrénie touche aussi les enfants et les adolescents : une des modalités de leur prise en charge est assurée par le CTJA [Centre thérapeutique de jour pour adolescents]

Abstract

1% des schizophrénies se déclenchent avant l'âge de 10 ans. 20%, une sur cinq, commencent avant l'âge de 18 ans. Et dans 40% des cas de schizophrénie avérée, les premiers signes étaient apparus avant 18 ans. En septembre 2003, CHUV-Magazine a fait le tour de la prise en charge des schizophrènes adultes. L'entretien avec le Dr Laurent Holzer, médecin associéau Centre thérapeutique de jour pour adolescents (CTJA), complète ce dossier en abordant le problème de la schizophrénie chez les jeunes. [Réd.]]]> Schizophrenia ; Child ; Adolescent fre oai:serval.unil.ch:BIB_2EC91B403AE6 2022-05-07T01:14:06Z openaire documents urnserval <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_2EC91B403AE6 Envelope glycoprotein of arenaviruses. info:doi:10.3390/v4102162 info:eu-repo/semantics/altIdentifier/doi/10.3390/v4102162 info:eu-repo/semantics/altIdentifier/pmid/23202458 Burri, D.J. Palma, J.R. Kunz, S. Pasquato, A. info:eu-repo/semantics/review article 2012 Viruses, vol. 4, no. 10, pp. 2162-2181 info:eu-repo/semantics/altIdentifier/eissn/1999-4915 urn:issn:1999-4915 <![CDATA[Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for the development of efficacious therapeutics an urgent need. Arenaviruses are comprised of two RNA genome segments and four proteins, the polymerase L, the envelope glycoprotein GP, the matrix protein Z, and the nucleoprotein NP. A crucial step in the arenavirus life-cycle is the biosynthesis and maturation of the GP precursor (GPC) by cellular signal peptidases and the cellular enzyme Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) yielding a tripartite mature GP complex formed by GP1/GP2 and a stable signal peptide (SSP). GPC cleavage by SKI-1/S1P is crucial for fusion competence and incorporation of mature GP into nascent budding virion particles. In a first part of our review, we cover basic aspects and newer developments in the biosynthesis of arenavirus GP and its molecular interaction with SKI-1/S1P. A second part will then highlight the potential of SKI-1/S1P-mediated processing of arenavirus GPC as a novel target for therapeutic intervention to combat human pathogenic arenaviruses