Cascio Wayne, E.

Danuser, Brigitta

Ghio Andrew, J.

Meier, Reto

Riediker, Michael

Wild, Pascal

Serveur académique lausannois

e aim of the symposium is to provide a scientic forum for researchers and practitioners to present and discuss the latest researches on occupational and environmental health issues of nanotechnolog y.■ Nanomaterial processing and characterization■ Health effects and toxicity (in vivo, in vitro) of manufactured nanomaterials■ ADME (Absorption, distribution, metabolism and excretion) and methodology  for kinetic study of manufactured nanomaterials■ Environmental toxicity of manufactured nanomaterials■ Exposure assessment in the workplaces producing  or handling manufactured nanomaterials■ Risk assessment of manufactured nanomaterials■ Risk management of manufactured nanomaterials■ Outreach for occupational and environmental health in nanotechnology■ Epidemiology on the workers exposed to manufactured nanomaterials■ Worker protection: Identifying and training the nanomaterial workforceTopicsOrganizershttp://square.umin.ac.jp/nanoeh6/　Contact address: nanoeh6-secretary@umin.orgDate:October28(Mon) 31(Thu), 2013Place:Venue:Nagoya, JapanNagoya Congress CenterJapan Committee for the 6th International Symposium on Nanotechnology, Occupational and Environmental Health / Planning Committee for the International Symposium on Nanotechnology, Occupational and Environmental HealthNanotechnology,Occupational and Environmental Health6th International Symposium on   47O-30-B-35 Particle and noise exposure of highway maintenance workers: cardiovascular short term health eﬀectsReto Meier1), Wayne E Cascio3), Andrew J Ghio3), Pascal Wild4), Brigitta Danuser1), Michael Riediker1,2)1)Institute for Work and Health, University of Lausanne, Switzerland, 2)IOM Singapore, Singapore, 3)Environmental Public Health Division, US EPA, NC, USA, 4)Institute for Research and Safety, FranceHighway maintenance workers are constantly exposed to traffic-related particle and noise emissions that both have been linked to increased cardiovascular morbidity and mortality. To investigate particle and noise related short term health eﬀects we monitored 18 maintenance workers, each for up to 5 times, during a total of 50 observation days. We measured their exposure to fine particulate matter (PM2.5), ultrafine particles and noise and assessed cardiopulmonary health endpoints. Blood pressure, pro-inﬂammatory and pro-thrombotic markers in the blood as well as lung function and fractional exhaled nitric oxide (FeNO) were measured approximately 15 hours post work, heart rate variability was assessed for a sleep period approximately 10 hours post work. PM2.5 exposure was related to increased C-reactive Protein and Serum Amyloid A levels and a decrease of TNFǂ. No signiﬁcant eﬀect could be observed on von Willebrand and Tissue Factor. PM2.5 and noise exposure during work were both related to an increase in heart rate variability. Increased high frequency power indicated a stronger parasympathetic influence on the heart. Blood pressure increased as a consequence of elevated noise levels during recreational time after work and we could see a trend towards higher blood pressure in relation to particle exposure. No eﬀects could be observed on lung function and FeNO. Our results show that combined exposure to particles and noise during highway maintenance work poses a cardiovascular health risk. Actions to reduce these exposures could lead to a better health of this worker population.This abstract does not necessarily represent US EPA policy.O-30-B-36 Eﬀects on Respiratory and Cardiovascular Systems in Workers Handling Titanium Dioxide ParticlesSahoko Ichihara1), Weihua Li2), Seiichi Omura3), Yuji Fujitani4), Ying Liu2), Qiangyi Wang2), Yusuke Hiraku5), Naomi Hisanaga6), Xuncheng Ding2), Takahiro Kobayashi3), Gaku Ichihara7)1)Mie University, Japan, 2)Shanghai Institute of Planned Parenthood Research, China, 3)Tokyo Institute of Technology, Japan, 4)National Institute for Environmental Studies, Japan, 5)Mie University Graduate School of Medicine, Japan, 6)Aichi University of Education, Japan, 7)Nagoya University Graduate School of Medicine, JapanTitanium dioxide (TiO2) is widely used as pigment, sunscreen, and photocatalyst. The present study assessed exposure levels in a factory handling TiO2 particles and the effects of such exposure on respiratory and cardiovascular systems. The diameter of primary particles collected on ﬁlters set in TiO2-handling factory in China was measured using scanning electron microscopy. Real time size-dependent particle number concentration was monitored and Holter monitors were attached to four workers before and during work. Health examination focusing on the respiratory and cardiovascular systems was conducted in the workers. The primary particle diameter ranged from 46 to 560 nm. The number concentration of particles with a diameter of more than 10, 5 to less than 10, 3 to less than 5, and 1 to less than 3 µm correlated negatively with the number concentration of nano-scaled particles. Multiple regression analysis showed that nano-scaled particle number and age correlated signiﬁcantly with the ratio of low frequency to high frequency heart rate variability, a parameter of sympathetic function. One worker showed pleural thickening on chest X-ray, but its association with exposure to TiO2 particles was not clear. The present study did not show clear abnormality in respiratory function in individuals who had worked for 10 months to 13 years in a factory with ambient mass concentration of TiO2 particles of 10-30 mg/m3. The study generated the hypothesis that aggregation of particles might reduce nano-scaled particles by absorption mechanism and that exposure to particles might aﬀect sympathetic function in elderly workers.

Particle and noise exposure of highway maintenance workers : cardiovascular short term health effects

https://serval.unil.ch/resource/serval:BIB_CB48C5CAA970.P001/REF.pdf

Particle and noise exposure of highway maintenance workers : cardiovascular short term health effects

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