Beckmann Jacques, S.

Bochud, Murielle

Marquant, F.

Marques-Vidal Pedro, Manuel

Mooser, Vincent

Paccaud, Fred

Rousson, Valentin

Vollenweider, Peter

Serveur académique lausannois

 Gènes et Environnement/GEN-6   Evidence of a causal association between C-reactive protein and adiposity in women.    1Bochud M., 1Marquant F., 1Marques-Vidal P.-M., 2Vollenweider P., 3Beckmann J., 4Mooser V., 1Paccaud F., 1Rousson V.    IUMSP - CHUV1, Internal Medicine - CHUV2, Medical Genetics - CHUV3, GlaxoSmithKline - USA4     Context: The link between C-reactive protein (CRP) and adiposity deserves to be further explored considering the diabetogenic role of CRP. Objective: We explored the potential causal role of CRP on adiposity markers. Design: We used a Mendelian randomization approach with the CRP and LEPR genes as instrumental variables in a cross-sectional Caucasian population-based study comprising 2526 men and 2836 women. Adiposity was measured using body mass index (BMI), fat and lean mass estimated by bioelectrical impedance, and waist circumference. Results: Log-transformed CRP explained by the rs7553007 SNP tagging the CRP gene was significantly associated with BMI (regression coefficient: 1.22 [0.18;2.25], P=0.02) and fat mass (2.67 [0.65;4.68], P=0.01), but not with lean mass in women, whereas no association was found in men. Log-transformed CRP explained by the rs1805096 LEPR SNP, located within exon 20, tended to be associated with BMI (0.70[-0.17;1.57], P=0.11) and fat mass (1.35[-0.32;3.02], P=0.11) in women, but not in men. The combined CRP-LEPR instrument explained 2.24% and 0.77% of CRP variance in women and in men, respectively. Log-transformed CRP explained by this combined instrument was significantly associated with BMI (0.98 [0.32 ;1.63], P=0.004), fat mass (2.07 [0.79 ;3.34], P=0.001) and waist (2.09 [0.39 ;3.78], P=0.01) in women, but not in men. Conclusion: Our results suggest that CRP is causally positively related to BMI in women, and that this is mainly due to fat mass. The similar results observed for the LEPR gene suggest that leptin may play a key role in the association between CRP and adiposity.        Table des matières     Message du Vice-Doyen de la  Recherche de a Faculté de Biologie et de Médecine    Programme      Abstracts  EHU  Environnement Humain  4 ENA  Environnement Naturel  27 GEN  Gènes et Environnement 31 IMI  Immunité et Infection 59 MCV  Métabolisme et Cardiovasculaire 97 NEU Neurosciences et Psyché 139 ODE  Oncologie et Développement 165 THE  Procédures Thérapeutiques 197   Index des auteurs  215    Couverture : Yannick Krempp, Département de Biologie Cellulaire et de Morphologie – UNIL   Photo : DNA microarray image of an RNA expression profiling experiment provided by  Manuela Weier and Henrik Kaessmann of the Centre Intégratif de Génomique - CIG and Jérôme Thomas of the Lausanne DNA Array Facility, Centre Intégratif de Génomique - CIG            Comité scientifique Jacques Beckmann, Service de Génétique médicale - CHUV Gé V  Poster Jury Karine Baumer, Institut de Pathologie – CHUV Di V Administration de la Recherche Jovan Mirkovitch, Faculté de Biologie et de Médecine – CHUV / UNIL Co      Comité d’organisation 2009    Nouria Hernandez, Centre intégratif de génomique - UNIL Ivan Stamenkovic, Institut de Pathologie – CHUV Amalio Telenti, Institut de Microbiologie – CHUV rard Waeber, Service de Médecine interne - CHU mitri Favre, Service de Médecine interne – CHUMarie-Aude Le Bitoux, Institut de Pathologie – CHUV Erwann Vieu, Centre intégratif de génomique – UNIL     Anne Tricot, Faculté de Biologie et de Médecine - UNIL raline Fraga, Faculté de Biologie et de Médecine - CHUV 

Evidence of a causal association between C-reactive protein and adiposity in women

https://serval.unil.ch/resource/serval:BIB_76A46086B1DF.P001/REF.pdf

Evidence of a causal association between C-reactive protein and adiposity in women

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