Obesity (Silver Spring)

Abstract

Objective:This study examined end-of-trial health outcomes in participants in the Look AHEAD (Action for Health in Diabetes) trial who had bariatric surgery during the approximately 10-year randomized intervention.Methods:Data were obtained from the Look AHEAD public access database of 4901 individuals with type 2 diabetes and overweight/obesity who were assigned to intensive lifestyle intervention (ILI) or a diabetes support and education (DSE) control group. Changes in outcomes in participants who had bariatric surgery were compared with those in participants with a body mass index (BMI) 65 30 kg/m2 who remained in the ILI and DSE groups.Results:A total of 99 DSE and 97 ILI participants had bariatric surgery. At randomization, these 196 participants were significantly younger and more likely to be female and to have higher BMIs than the remaining ILI (N=1972) and DSE (N=2009) participants. At trial\u2019s end, surgically-treated participants lost 19.3% of baseline weight, compared with 5.6% and 3.3% for the ILI and DSE groups, respectively, and were more likely to achieve partial or full remission of their diabetes.Conclusions:The large, sustained improvements in weight and diabetes observed in this self-selected sample of surgically-treated participants are consistent with results of multiple randomized trials.U01 DK057151/DK/NIDDK NIH HHS/United StatesP30 DK048520/DK/NIDDK NIH HHS/United StatesU01 DK057135/DK/NIDDK NIH HHS/United StatesUL1 RR024153/RR/NCRR NIH HHS/United StatesP30 DK046204/DK/NIDDK NIH HHS/United StatesM01 RR002719/RR/NCRR NIH HHS/United StatesM01 RR000056/RR/NCRR NIH HHS/United StatesU01 DK057219/DK/NIDDK NIH HHS/United StatesU01 DK057154/DK/NIDDK NIH HHS/United StatesU01 DK056992/DK/NIDDK NIH HHS/United StatesU01 DK057171/DK/NIDDK NIH HHS/United StatesU01 DK057182/DK/NIDDK NIH HHS/United StatesU01 DK057136/DK/NIDDK NIH HHS/United StatesU01 DK057002/DK/NIDDK NIH HHS/United StatesU01 DK057177/DK/NIDDK NIH HHS/United StatesM01 RR001066/RR/NCRR NIH HHS/United StatesU01 DK057078/DK/NIDDK NIH HHS/United StatesU01 DK057131/DK/NIDDK NIH HHS/United StatesM01 RR000051/RR/NCRR NIH HHS/United StatesM01 RR000043/RR/NCRR NIH HHS/United StatesU01 DK056990/DK/NIDDK NIH HHS/United StatesU01 DK057178/DK/NIDDK NIH HHS/United StatesU01 DK057008/DK/NIDDK NIH HHS/United StatesU01 DK057149/DK/NIDDK NIH HHS/United StatesK23 NR017209/NR/NINR NIH HHS/United StatesM01 RR001346/RR/NCRR NIH HHS/United StatesK23 NR017209/NR/NINR NIH HHS/United States2020-04-01T00:00:00Z30900413PMC6432947693