Gallium Containing Glass Polyalkenoate Anti-Cancerous Bone Cements: Glass Characterization and Physical Properties

Abstract

A gallium (Ga) glass series (0.48SiO2-0.40ZnO-0.12CaO, with 0.08 mol% substitution for ZnO) was developed to formulate a Ga-containing Glass Polyalkenoate Cement (GPC) series. Network connectivity (NC) and X-ray Photoelectron Spectroscopy (XPS) was employed to investigate the role of Ga3+ in the glass, where it is assumed to act as a network modifier. Ga-GPC series was formulated with E9 and E11 polyacrylic acid (PAA) at 50, 55 and 60 wt% additions. E11 working times (Tw) ranged from 68 to 96 s (Lcon.) and 106 s for the Ga-GPCs (LGa-1 and LGa-2). Setting times (Ts) ranged from 104 to 226 s (Lcon.) and 211 s for LGa-1 and LGa-2. Compression (δc) and biaxial flexural (δf) testing were conducted where Lcon. increased from 62 to 68 MPa, LGa-1 from 14 to 42 MPa and LGa-2 from 20 to 47 MPa in δc over 1-30 days. δf testing revealed that Lcon. increased from 29 to 42 MPa, LGa-1 from 7 to 32 MPa and LGa-2 from 12 to 36 MPa over 1-30 days. © 2012 Springer Science+Business Media, LLC