Socioeconomic inequality is on the rise in major European cities, as are concerns over it, since it is seen as a threat to social cohesion and stability. Surprisingly, relatively little is known about the spatial dimensions of rising socioeconomic inequality. This paper builds on a study of socioeconomic segregation in 12 European cities: Amsterdam, Athens, Budapest, London, Madrid, Oslo, Prague, Riga, Stockholm, Tallinn, Vienna, and Vilnius. Data used derive from national censuses and registers for 2001 and 2011. The main conclusion is that socioeconomic segregation has increased. This paper develops a rigorous multifactor approach to understand segregation and links it to four underlying, partially overlapping, structural factors: social inequalities, globalization and economic restructuring, welfare regimes, and housing systems. Taking into account contextual factors resulted in a better understanding of actual segregation levels, while introducing time lags between structural factors and segregation outcomes will likely further improve the theoretical model