This article is dedicated to the research of analysis of the dependence of growth and development of winter wheat varieties Khersonska Awnless and Odeska 267 on conditions of moisture provision and mineral nutrition status, impact of indicated factors and formation of yielding capacity and grain quality. Years of research significantly varied in rainfall amount during growing season. According to moisture supply, 2016 was dry, 2017 was average humid and 2018 was subhumid, which had an impact on grain yield equation. The lowest winter wheat productivity level was formed in 2016. Under supplemental watering without fertilizers the yield of the Khersonska Awnless variety was at the level 2.07 t/ha, and of Odeska 267 variety - 1.51 t/ha. Under provision of vegetative watering, the yielding capacity increased to 3.14 and 2.94 t/ha. Fertilizers also had significant impact on production processes of plants, accumulation of over ground biomass, area of assimilating surface that resulted in the yield increase of winter wheat. On average, over the years of research the most significant influence among considered factors had fertilizers - 43%, irrigation - 32% and variety content of winter wheat - 9%