Benzodiazepines are an important class of heterocyclic compounds in organic
chemistry. They are known for their diverse physicochemical and biological properties.
Some benzodiazepine derivates are well-known drugs with diverse and strong
pharmacophoric moiety. An immense number of pharmacological research on
benzodiazepine heterocycles and their derivatives have recently been conducted to
explore its numerous pharmacological potentials as better therapeutic candidates for
the treatment of various disorders, benzodiazepines, however, are one of the main
sources of interest for many medicinal chemists. Researchers are drawn to the
benzodiazepine nucleus for the synthesis of new drugs because of its potent
pharmacophoric moiety and ring shape. Due to the emergence of new pathogenic
strains’ resistance to the presently available drugs, there has been a constant demand
for more effective and selective drugs. Benzodiazepine moiety has all the desired
qualities for selective drug candidates used as useful therapeutic agents. Given the importance of benzodiazepine moiety, the current review aims to assess
benzodiazepine syntheses as well as their pharmacological properties for potential
molecular targets in therapeutic development