Background: Programmed death-ligand 1 (PD-L1) may be induced by oncogenic signals or
can be upregulated via interferon gamma (IFN-y). We have explored whether the expression
of IFNG, the gene encoding IFN-y, is associated with clinical response to the immune
checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma patients. The role
of inflammation-associated transcription factors STAT3, IKBKE, STAT1 and other associated
genes has also been examined
