Aptamers are single-stranded oligonucleotides (ssDNA or ssRNA) that bind and recognize
their targets with high affinity and specificity due to their complex tertiary structure. Aptamers are
selected by a method called SELEX (Systematic Evolution of Ligands by EXponential enrichment).
This method has allowed the selection of aptamers to different types of molecules. Since then, many
aptamers have been described for the potential treatment of several diseases including cancer. It has
been described over the last few years that aptamers represent a very useful tool as therapeutics,
especially for cancer therapy. Aptamers, thanks to their intrinsic oligonucleotide nature, present
inherent advantages over other molecules, such as cell-based products. Owing to their higher tissue
penetrability, safer profile, and targeting capacity, aptamers are likely to become a novel platform for
the delivery of many different types of therapeutic cargos. Here we focus the review on interfering
RNAs (iRNAs) as aptamer-based targeting delivered agents. We have gathered the most reliable
information on aptamers as targeting and carrier agents for the specific delivery of siRNAs, shRNA,
microRNAs, and antisense oligonucleotides (ASOs) published in the last few years in the context of
cancer therapy