Tailored cancer therapy by magnetic nanoparticle hyperthermia: A virtual scenario simulation method

Abstract

[EN] Background and objective: Hyperthermia is a cancer treatment aiming to induce cell death by directly warming cancerous tissues above 40 degrees C. This technique can be applied both individually and together with other cancer therapies. The main challenge for researchers and medics is to heat only tumoral cells avoiding global or localized heating of sane tissues. The objective in this study is to provide a realistic virtual scenario to develop an optimized multi-site injection plan for tailored magnetic nanoparticlemediated hyperthermia applications. Methods: A three-dimensional model of a cat's back was tested in three different simulation scenarios, showing the impact of magnetic nanoparticles in each specific environment configuration. Results: As a result of this study. This simulation method can, minimising the affection to healthy tissue. Conclusions: This virtual method will help real and personalized therapy planning and tailor the dose and distribution of magnetic nanoparticles for an enhanced hyperthermia cancer treatment.Financial support from FEDER and the Spanish Government (projects MAT2015-64139-C4-3-R, MAT2015-64139-C4-1-R and RTI2018-100910-B-C43 (MINECO/FEDER)), the Generalitat Valenciana (PROMETEOII/2014/047) and the UPV (PAID) is gratefully acknowledged by the authors. This work was in part also financially supported by the Swiss National Science Foundation (SNSF), financed by the Swiss Confederation under the Nano-Tera.ch program, (Magnetotheranostics, project No 530 627).Montes-Robles, R.; Montanaro, H.; Capstick, M.; Ibáñez Civera, FJ.; Masot Peris, R.; Garcia-Breijo, E.; Laguarda-Miro, N.... (2022). Tailored cancer therapy by magnetic nanoparticle hyperthermia: A virtual scenario simulation method. Computer Methods and Programs in Biomedicine. 226:1-10. https://doi.org/10.1016/j.cmpb.2022.10718511022