Purpose: The main objective of this study was to investigate
the microbiological spectrum of endophthalmitis after anti-
VEGF injections and to compare streptococcal with nonstreptococcus-
associated cases with regard to baseline characteristics and injection procedure. Methods: Retrospective,international multicenter study of patients with culture-positive
endophthalmitis after intravitreal anti-VEGF injection at
17 different retina referral centers. Results: Eighty-three cases
with 87 identified pathogens were included. Coagulasenegative
staphylococci (59%) and viridans streptococci
(15%) were the most frequent pathogens found. The use of
postoperative antibiotics and performance of injections in
an operating room setting significantly reduced the rate of
streptococcus-induced endophthalmitis cases (p = 0.01 for
both). Conclusion: We found a statistically significant lower
rate of postinjectional local antibiotic therapy and operating
room-based procedures among the streptococcus-induced
cases compared to cases caused by other organisms
