PHARMACOLOGICAL MANAGEMENT OF ANXIETY ON PAIN OCCURRENCE DURING ROOT CANAL TREATMENT: A SYSTEMATIC REVIEW

Abstract

This study aims to answer the question: “Does the pharmacological management of dental anxiety influence on pain occurrence during root canal treatment?” Searches on MEDLINE/PubMed, Cochrane Library, Web of Science, Scopus, EMBASE and Open Grey were conducted until February 2021. Only randomized clinical trials were included. Cochrane risk of bias tool for randomized trials (RoB 2) was used. Overall quality of evidence was assessed through the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool. Initial screening resulted in 510 studies. 43 were excluded for being duplicates. Of 467 eligible papers, ten studies met the inclusion criteria and were selected for full-text reading and four studies were included for final analysis. GRADE analysis demonstrated a low quality of evidence. There is no sufficient evidence to determine whether the pharmacological control of anxiety can influence in the intraoperative pain occurrence