CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Effectiveness of third-class biologic treatment in crohn’s disease : A multi-center retrospective cohort study
Authors
Manuel Barreiro De Acosta
Waqqas Afif
+44 more
Ahmad Albshesh
Catarina Alves
Hadar Amir-Barak
Alessandro Armuzzi
Mohamed Attauabi
Johan Burisch
Maria Chaparro
Marina Coletta
Anneline Cremer
Caroline Di Jiang
Viktor Domislovic
David Drobne
Carl Eriksson
Morine Fibelman
Kalliopi Foteinogiannopoulou
Javier P. Gisbert
Konstantinos Karmiris
Uri Kopylov
Mohamed Korani
Ioannis Koutroubakis
Zeljko Krznaric
Claire Liefferinckx
Jimmy K. Limdi
Triana Lobaton
Fernando Magro
Nitsan Maharshak
Carla Marinelli
Pauliina Molander
Tamás Molnár
Afroditi Mpitouli
Stephane Nancey
Borja Otero-Alvarin
Daniela Pugliese
Tim Raine
Davide G. Ribaldone
Mariann Rutka
Edoardo V. Savarino
Jakob Seidelin
Ariella Bar Gil Shitrit
Gerard Suris
Joshua Taylor
Katja Tepeš
Marie Truyens
Henit Yanai
Publication date
1 January 2021
Publisher
Doi
Cite
Abstract
Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Background: Multiple studies have described the effectiveness of ustekinumab (UST) and vedolizumab (VDZ) in patients with Crohn’s disease (CD) failing anti-Tumor necrosis factors (TNFs); however, the effectiveness of VDZ or UST as a third-class biologic has not yet been described. Aims and Methods: In this retrospective multicenter cohort study, we aimed to investigate the effectiveness of VDZ and UST as a third-class biologic in patients with CD. Results: Two-hundred and four patients were included; 156/204 (76%) patients received VDZ as a second-and UST as a third-class therapy (group A); the remaining 48/204 (24%) patients received UST as a second-and VDZ as a third-class therapy (group B). At week 16–22, 87/156 (55.5%) patients and 27/48 (56.2%) in groups A and B, respectively, responded to treatment (p = 0.9); 41/156 (26.2%) and 15/48 (31.2%) were in clinical remission (p = 0.5). At week 52; 89/103 (86%) patients and 25/29 (86.2%) of the patients with available data had responded to third-class treatment in groups A and B, respectively (p = 0.9); 31/103 (30%) and 47/29 (24.1%) were in clinical remission (p = 0.5). Conclusion: Third-class biological therapy was effective in more than half of the patients with CD. No differences in effectiveness were detected between the use of VDZ and UST as a third-class agent.Peer reviewe
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Ghent University Academic Bibliography
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:archive.ugent.be:8714746
Last time updated on 05/12/2021
Directory of Open Access Journals
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:doaj.org/article:34fbf772a...
Last time updated on 30/10/2021
Institutional Research Information System University of Turin
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:iris.unito.it:2318/1793516
Last time updated on 14/12/2021
Sustaining member
Apollo (Cambridge)
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:www.repository.cam.ac.uk:1...
Last time updated on 28/08/2021
University of Zagreb Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:repozitorij.unizg.hr:mef_4...
Last time updated on 29/06/2022
Veterinary medicine - Repository of PHD, master's thesis
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:repozitorij.mef.unizg.hr:m...
Last time updated on 29/06/2022
Diposit Digital de la Universitat de Barcelona
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:diposit.ub.edu:2445/179326
Last time updated on 31/10/2021
Copenhagen University Research Information System
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:pure.atira.dk:publications...
Last time updated on 03/12/2021
DI-fusion
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:dipot.ulb.ac.be:2013/33474...
Last time updated on 11/01/2022
Helsingin yliopiston digitaalinen arkisto
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:helda.helsinki.fi:10138/34...
Last time updated on 28/02/2022