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Auer, Doris

Hill, Christian

Hohenester, Ulrich

Simic, Marko

English

Engineering Conferences International

PROCESS ANALYTICS WITH OPTOFLUIDIC FORCE INDUCTION (OF2I). A BRAVE NEW WAY IN ONLINE PARTICLE CHARACTERIZATION.  Christian Hill, Medical University of Graz, Brave Analytics GmbH christian.hill@medunigraz.at Marko Simic, Medical University of Graz, Brave Analytics GmbH, University of Graz, Universitätsplatz 5, 8010 Graz, AT  Doris Auer, Medical University of Graz, Brave Analytics GmbH Ulrich Hohenester, University of Graz, Universitätsplatz 5, 8010 Graz, AT   Key Words: nano-particle characterization, process analytical technology, process feedback, microfluidic  Measuring nanoparticle size distributions (PSD), continuously and in real-time is still one of the most challenging tasks within modern particle engineering- and production environments. Here we show a fast and new approach, Opto-Fluidic Force Induction (OF2i®) [1,2], which tackles the high requirements as a Process Analytical Technology (PAT) tool. In contrast to conventional Brownian motion or scattering-based technologies, OF2i uses a novel approach utilizing optical forces - the basic principle of optical tweezers, which have been awarded the Nobel Prize in Physics 2018 [3]  - for (de)accelerating of simultaneously trapped particle ensembles in a micro fluidic flow cell [Fig. 1].        Our measurement scheme is applied to different particle systems and evaluated within our theoretical framework, where we also monitor evolutionary processes over large time scales. This dynamic approach allows for real-time monitoring of feedback parameters such as particle size, size-distribution, turbidity, and concentration which can be used to adapt process parameters. Our results prove that OF2i can provide a flexible work bench for numerous industrial, pharmaceutical, and technological applications.  [1] M. Simic, et al. Physical Review Applied 18, 024056 (2022); [2] C. Hill. (2020). EU Patent No. 3422364B1. European Patent Office.; [3] Ashkin A., PNAS 1997, 94, 48534860. Figure 1 – sketch of the basic OF2i principle comprising (a) a sample flowing through a microfluidic sample cell, (b) a weakly focused optical vortex beam extrinsically trapping particle ensembles to avoid particle to particle obstructions for unhindered (de)acceleration and scattering light detection as a counting particle principle and (c) the main force components acting on the particle ensembles  

Process analytics with OptoFluidic Force Induction (OF2i). A BRAVE new way in online particle characterization

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Process analytics with OptoFluidic Force Induction (OF2i). A BRAVE new way in online particle characterization

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Engineering Conferences International