This study aims to determine the factor affecting the incidence of postpartum depression in adolescent mothers. The incidence of postpartum depression is quite high in Asia. The highest percentage occurred when having a first child and family history of mood disorders. The cause of this issue is varied. This study used a cross-sectional approach. The study was conducted from May 2021 to March 2022. It involved a total of 886 adolescent mothers as respondents. The instrument used the Edinburg Postnatal Depression Scale (EDPS) questionnaire. Multiple logistic regression was used to estimate the factors associated with postpartum depression. the prevalence of Postpartum depression is 50.68%. Family monthly income (95%CI: 4.09-6.75, p-value: 0.001), planned pregnancy (95%CI: 1.26-4.9, p-value: 0.000), wanted pregnancy (95%CI: 2.37-5.67, p- value: 0.001), type of delivery (95%CI: 4.39 β 5.21, p-value: 0.002), satisfied with baby's sex (95%CI: 4.39 β 5.21, p-value: <0.000), husband support (95% CI: 2.89-5.88, p-value: 0.000) were statistically significant with postpartum depression. Mothers with postpartum depression have a negative impact on themselves, their babies, and their families