It has been revealed that reproductive function and metabolic function interact with each other. Disturbance of metabolic/nutritional conditions suppress reproductive functions and consequently induce ovulatory disorder and infertility. Some hypothalamic neuroendocrine factors are involved in these alterations. Conversely, gonadal hormonal milieu affects metabolic/nutritional functions and stress response, and these actions of androgens are drastically changed by estrogen milieu. These interactions may play pivotal role in homeostasis and adaption to some adverse conditions
