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Supplementation with long chain n-3 fatty acids during pregnancy, lactation, or infancy in relation to risk of asthma and atopic disease during childhood : a systematic review and meta-analysis of randomized controlled clinical trials
Authors
Erik Kristoffer Arnesen
Linnea Bärebring
+7 more
Jutta Dierkes
Christel Lamberg-Allardt
Bright I. Nwaru
Alfons Ramel
Fredrik Söderlund
Birna Thorisdottir
Agneta Åkesson
Publication date
11 October 2022
Publisher
'SNF Swedish Nutrition Foundation'
Doi
Cite
Abstract
Funding Information: This systematic review was conducted according to the guidelines for systematic reviews, developed for the 2022 revision of the NNR (23, 24) and Preferred reporting for systematic reviews (25). The NNR 2022 is funded by the Nordic Council of Ministers and governmental food and health authorities of Norway, Finland, Sweden, Denmark, and Iceland (26). A study protocol was published prior to article selection in the database PROSPERO (https://www.crd.york.ac.uk, CRD42021275309). Publisher Copyright: © 2022 Linnea Bärebring et al.Objective: To assess whether supplementation with long chain n-3 fatty acids during pregnancy, lactation, or infancy reduces the risk of developing asthma or atopic disease during childhood. Methods: Searches were performed in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and Scopus up to 2021-09-20, for randomized controlled trials (RCTs) that investigated the effect of supple-mental long chain n-3 fatty acids during pregnancy, lactation, or infancy for the prevention of childhood asthma or allergy. Article selection, data extraction, and risk of bias assessment (Cochrane’s Risk of Bias 2.0) were independently conducted by two assessors. The evidence was synthesized qualitatively according to the criteria of the World Cancer Research Fund and meta-analyzed. Results: A total of nine RCTs met inclusion criteria; six were conducted during pregnancy, two during infancy, and one during both pregnancy and infancy. Meta-analysis showed that long chain n-3 fatty acid supplementation during pregnancy significantly reduced the risk of asthma/wheeze in the child (RR 0.62 [95% confidence interval 0.34–0.91], P = 0.005, I2 = 67.4%), but not other outcomes. Supplementation during lactation of infancy showed no effects on any outcome. The strength of evidence that long chain n-3 fatty acid supplementation during pregnancy reduces risk of asthma/wheeze in the offspring was con-sidered limited – suggestive. No conclusion could be made for the effects of long chain n-3 fatty acid supplementation during pregnancy for other atopic diseases, or for supplementation during lactation or infancy for any outcome. Conclusion: The intake of long chain n-3 fatty acid supplements during pregnancy may reduce the risk of asthma and/or wheeze in the offspring, but the strength of evidence is low. There is inconclusive evidence for the effects of long chain n-3 fatty acid supplements during pregnancy for other outcomes, as well as for sup-plementation during lactation or infancy.Peer reviewe
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Last time updated on 09/03/2023