Schiff-base compounds have been utilized in the medical field as antibiotics, antifungal, anti-inflammatory and antiviral agents. The presence of nitrogen, oxygen and sulphur atoms in chelating Schiff-base compounds showed great biological activities. Furthermore, their derivative metal complexes have exhibited greater effects in many reported cases. Some Schiff-base complexes have been reported as medical imaging agents. The aim of my work is to synthesis novel Schiff base ligands and their metal derivatives that have the potential to be used as medical imaging precursors. A novel macrocyclic Schiff-base ligand was developed from 3,5- diformyl-4-hydroxybenzoic acid and 2,2’-oxydianiline. Also, a novel crystal structure for a known macrocyclic Schiff-base was synthesized from 2,2’-oxydianiline and 4-tert-butyl-2,6-diformylphenol. Finally, a novel copper Schiff-base complex synthesized
