Synthesis and investigation of biological activity of arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone

Abstract

Sintetisana su dva ariltio i dva aralkiltio derivata 2-terc-butil-1,4-benzohinona reakcijom Michael-ove adicije tiola na hinonsko jezgro u etanolu. Dobijenim derivatima je ispitana antimikrobna i antioksidativna aktivnost, kao i toksinost na raie Artemia salina. Najjau antimikrobnu aktivnost je pokazao derivat 4, najveu antioksidativnu aktivnost je imao derivat 2 (IC50=0,0526 mM), dok je toksinost prema raiima ispoljio samo derivat 4 (LC50=0,032 mM).Two arylthio and aralkylthio derivatives of 2-tert-butyl-1.4-benzoquinone were synthesized by Michael addition of thiols on quionone moiety in ethanol. For all compounds antimicrobial and antioxidant activity was investigated, as well as toxicity towards nauplii of Artemia salina. Derivative 4 showed the strongest antimicrobial activity, derivative 2 showed the most intense antioxidant activity (IC50=0.0526 mM), while only derivative 4 showed toxicity against nauplii of A. salina (LC50=0.032 mM)

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