Synthesis of N‐(9H‐Xanthen‐9‐yl)aminoalkanamide and N‐(9H‐Thioxanthen‐9‐yl)aminoalkanamide Derivatives and their in vitro Evaluation as Potential Intercalators and Antitumor Drugs

Abstract

A series of new N‐(9H‐xanthen‐9‐yl)aminoalkanamide and N‐(9H‐thio‐xanthen‐9‐yl)aminoalkanamide derivatives was synthesized and evaluated as potential intercalators by measuring their DNA binding affinity. They were also tested for cytotoxic activity against L1210. The results suggest that the cytotoxicity of these molecules was not due to an intercalating mechanism. Copyright © 1994 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinhei