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Lenalidomide with low- or intermediate-dose dexamethasone in patients with relapsed or refractory myeloma
Authors
F. Zagouri Roussou, M. Kastritis, E. Gavriatopoulou, M. Eleutherakis-Papaiakovou, E. Kanellias, N. Kalapanida, D. Christoulas, D. Migkou, M. Terpos, E. Dimopoulos, M.A.
Publication date
1 January 2016
Publisher
Abstract
Abstract: To compare the outcomes of patients with relapsed or refractory multiple myeloma (RRMM) who were treated with lenalidomide combined with high versus low dose of dexamethasone. One hundred forty consecutive relapsed or refractory multiple myeloma (RRMM) patients who received lenalidomide with dexamethasone, in two consecutive time periods, were divided into two groups: group RD (70 consecutive patients in the first period) who received lenalidomide with intermediate doses of dexamethasone and group Rd (70 consecutive patients in the more recent period) who received lenalidomide with low-dose dexamethasone. 62% and 73% of patients who received RD and Rd (p = 0.148) achieved at least a partial response, accordingly. The median OS was 20 and 41 months for the RD and the Rd group, accordingly. In the multivariate analysis, Rd was associated with improved PFS. More patients treated with RD developed grade 3&4 neutropenia and fatigue. It seems that Rd is at least as effective as RD. © 2016 Informa UK Limited, trading as Taylor & Francis Group
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Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
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oai:lib.uoa.gr:uoadl:3087204
Last time updated on 10/02/2023
Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:lib.uoa.gr:uoadl:2951314
Last time updated on 10/02/2023