CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Mitochondrial DNA copy-number variation and pancreatic cancer risk in the prospective EPIC cohort
Authors
M. Gentiluomo Katzke, V.A. Kaaks, R. Tjønneland, A. Severi, G. Perduca, V. Boutron-Ruault, M.-C. Weiderpass, E. Ferrari, P. Johnson, T. Schulze, M.B. Bergmann, M. Trichopoulou, A. Karakatsani, A. Vecchia, C.L. Palli, D. Grioni, S. Panico, S. Tumino, R. Sacerdote, C. Bueno-De-Mesquita, B. Vermeulen, R. Sandanger, T.M. Ramón Quirós, J. Rodriguez-Barranco, M. Amiano, P. Colorado-Yohar, S. Ardanaz, E. Sund, M. Khaw, K.-T. Wareham, N.J. Schmidt, J.A. Jakszyn, P. Morelli, L. Canzian, F. Campa, D.
Publication date
1 January 2020
Publisher
Abstract
Background: Mitochondrial DNA (mtDNA) copy number in peripheral blood has been found to be associated with risk of developing several cancers. However, data on pancreatic ductal adenocarcinoma (PDAC) are very limited. Methods: To further our knowledge on this topic, we measured relative mtDNA copy number by a quantitative real-time PCR assay in peripheral leukocyte samples of 476 PDAC cases and 357 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Results: We observed lower mtDNA copy number with advancing age (P = 6.54 x 10-5) and with a high body mass index (BMI) level (P = 0.004) and no association with sex, smoking behavior, and alcohol consumption. We found an association between increased mtDNA copy number and decreased risk of developing PDAC with an odds ratios (OR) of 0.35 [95% confidence interval (CI), 0.16-0.79; P = 0.01] when comparing the fifth quintile with the first using an unconditional logistic regression and an OR of 0.19 (95% CI, 0.07-0.52; P = 0.001) with a conditional analysis. Analyses stratified by BMI showed an association between high mtDNA copy number and decreased risk in the stratum of normal weight, consistent with the main analyses. Conclusions: Our results suggest a protective effect of a higher number of mitochondria, measured in peripheral blood leukocytes, on PDAC risk. Impact: Our findings highlight the importance of understanding the mitochondrial biology in pancreatic cancer. © 2020 American Association for Cancer Research
Similar works
Full text
Available Versions
Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:lib.uoa.gr:uoadl:3105187
Last time updated on 10/02/2023