The role of transforming growth factor beta in thyroid autoimmunity:
current knowledge and future perspectives
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Abstract
The complex mechanisms, which are related to the pathophysiology and the
development of autoimmune thyroid diseases, involve transforming growth
factor beta (TGF-beta) and its interplay with the immune system. The aim
of this review is to examine the role of TGF-beta regarding thyroid
autoimmunity and explore the potent role of this molecule either as a
diagnostic or prognostic marker or a therapeutic target regarding
autoimmune thyroid diseases. TGF-beta is clearly a master regulator of
the immune response, exerting either inhibitory or facilitatory effects
on cells of the immune system. Thus, this molecule is involved in the
pathogenesis and development of autoimmune thyroid diseases. Recent
research has revealed the involvement of TGF-beta in the pathophysiology
of autoimmune thyroid diseases. The role of TGF-beta in the development
of autoimmune thyroid diseases varies, depending on its concentrations,
the type of the activated TGF-beta signalling pathway, the genetic
predisposition of the patient and the pathophysiologic stage of the
disease. TGF-beta could emerge as a useful diagnostic or prognostic
marker for the evolution of thyroid autoimmunity. Promising perspectives
for the effective therapeutic use of TGF-beta regarding thyroid
autoimmunity exist. The main treatment approaches incorporate either
enhancement of the immunosuppressive role of TGF-beta or inhibition of
its facilitatory role in the autoimmune thyroid diseases. Further
research towards deeper understanding of TGF-beta physiology and
clinical application of its possible therapeutic role regarding thyroid
autoimmunity is needed