This is the case of a 43-year-old Caucasian man with frequent episodes
of paroxysmal atrial fibrillation (AF) and normal resting
electrocardiogram (ECG), who fulfilled two minor diagnostic criteria for
arrhythmogenic right ventricular cardiomyopathy (ARVC): late potentials
by signal-averaged ECG and regional right ventricular outflow tract
(RVOT) dyskinesia with mildly dilated RVOT end-diastolic diameter.
Genetic test results revealed a disease-associated missense mutation in
DSC2 (p.E102K), adding a major diagnostic criterion according to
recently published modified Task Force Criteria. However, 2 years after
successful ablative therapy for AF, the patient remains completely
asymptomatic, without any clinical signs of ARVC. Both ventricular and
supraventricular arrhythmias had vanished after AF ablation. Our patient
mainly suffered AF without significant ventricular arrhythmias, a very
uncommon clinical presentation of ARVC. Copyright (C) 2012 S. Karger AG,
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