Background: Since the beginning of the COVID-19 pandemic, the world’s attention has been focused on better understanding
the relation between the human host and the SARS-CoV-2 virus, as its action has led to hundreds of thousands of deaths.
Objective: In this context, we decided to study certain consequences of the abundant cytokine release over the innate and
adaptive immune systems, inflammation, and hemostasis, comparing mild and severe forms of COVID-19.
Methods: To accomplish these aims, we will analyze demographic characteristics, biochemical tests, immune biomarkers,
leukocyte phenotyping, immunoglobulin profile, hormonal release (cortisol and prolactin), gene expression, thromboelastometry,
neutralizing antibodies, metabolic profile, and neutrophil function (reactive oxygen species production, neutrophil extracellular
trap production, phagocytosis, migration, gene expression, and proteomics). A total of 200 reverse transcription polymerase chain
reaction–confirmed patients will be enrolled and divided into two groups: mild/moderate or severe/critical forms of COVID-19.
Blood samples will be collected at different times: at inclusion and after 9 and 18 days, with an additional 3-day sample for severe
patients. We believe that this information will provide more knowledge for future studies that will provide more robust and useful
clinical information that may allow for better decisions at the front lines of health care.
Results: The recruitment began in June 2020 and is still in progress. It is expected to continue until February 2021. Data analysis
is scheduled to start after all data have been collected. The coagulation study branch is complete and is already in the analysis
phase
