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Design and synthesis of new pyranoxanthenones bearing a nitro group or an aminosubstituted side chain on the pyran ring. Evaluation of their growth inhibitory activity in breast cancer cells
Authors
G. Kolokythas Kostakis, I.K. Pouli, N. Marakos, P. Kousidou, O.Ch. Tzanakakis, G.N. Karamanos, N.K.
Publication date
1 January 2007
Publisher
Abstract
Some new 2,6-disubstituted pyrano- and 1,2-dihydropyrano[2,3-c]xanthen-7-ones have been synthesized and their antiproliferative activity has been evaluated against MDA-MB-231 breast cancer cells. The antiproliferative activity evaluation of the compounds provided evidence that a dimethylamino substituted side chain and the presence of 1,2 double bond play a key role in cell growth inhibition. Among the tested derivatives the 6-dimethylaminoethylamino-2-nitropyranoxanthenone analogue possessed a significant inhibitory effect in a wide range of concentrations. © 2006 Elsevier Masson SAS. All rights reserved
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Last time updated on 10/02/2023