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Synthesis of novel conformationally constrained pyrazolo[4,3-c]quinoline derivatives as potential ligands for the estrogen receptor
Authors
K.M. Kasiotis Fokialakis, N. Haroutounian, S.A.
Publication date
1 January 2006
Publisher
Abstract
The preparation of three novel classes of pyrazolo[4,3-c]quinoline derivatives is reported. The easily accessible 2,3-dihydro-1H-quinolin-4-ones were used as the starting materials and were functionalized with three different acylating agents affording their respective constrained core substrates. The latter by condensation with phenyl(or 4-methoxyphenyl)hydrazines and subsequent debenzylation or demethylation provided the desired pyrazole derivatives. Some interesting features emerged with respect to the regioselectivity and mechanism of these reactions. © Georg Thieme Verlag Stuttgart
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Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
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oai:lib.uoa.gr:uoadl:2981917
Last time updated on 10/02/2023