Stem cells have been considered as possible therapeutic vehicles for
different health related problems such as cardiovascular and
neurodegenerative diseases and cancer. Secreted molecules are key
mediators in cell-cell interactions and influence the cross talk with
the surrounding tissues. There is strong evidence supporting that
crucial cellular functions such as proliferation, differentiation,
communication and migration are strictly regulated from the cell
secretome. The investigation of stem cell secretome is accumulating
continuously increasing interest given the potential use of these cells
in regenerative medicine. The scope of the review is to report the main
findings from the investigation of stem cell secretome by the use of
contemporary proteomics methods and discuss the current status of
research in the field. This article is part of a Special Issue entitled:
An Updated Secretome. (C) 2013 Elsevier B.V. All rights reserved
