Study design, materials, and methods. aEuro integral We combined the
analysis of polymorphisms of the GSTP1, eNOS, and LPL genes – affecting
biotransformation enzymes and endothelial function – in a cohort of 167
preeclamptic and normal control trios (mother, father, and child)
comprising a total of 501 samples in the Greek population, never
analyzed before by this approach.
Results. aEuro integral For the frequency of the GSTP1
Ile<SU105</SU/Val<SU105</SU, the eNOS Glu298Asp and the LPL-93
polymorphisms, statistically significant differences were found between
the two groups. However, the transmission rates of the parental alleles
to neonates studied by the transmission disequilibrium test, disclosed
no increased rate of transmission to preeclampsia children for the
variant alleles of Val<SU105</SU GSTP1, 298Asp eNOS, and -93G LPL.
Conclusions. aEuro integral These novel data, suggest that interaction
of all three types of genotypes (mother, father and neonate), reveals no
effects on the development of preeclampsia, but provide the impetus for
further studies to decipher the individual contribution of each genetic
parameter of preeclampsia
