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Interobserver variability, and visual and quantitative parameters of 123I-FP-CIT SPECT (DaTSCAN) studies
Authors
N. Papathanasiou Rondogianni, P. Chroni, P. Themistocleous, M. Boviatsis, E. Pedeli, X. Sakas, D. Datseris, I.
Publication date
1 January 2012
Publisher
Abstract
Objective To evaluate the degree of interobserver agreement in the visual interpretation of 123I-FP-CIT studies and to investigate for potential associations between visual and semi-quantitative parameters. Methods Eighty-nine 123I-FP-CIT studies were blindly reviewed by 3 independent observers: a consultant, a resident doctor and a radiographer. They classified every study as either "normal" or "abnormal" and assigned visual 123I-FP-CIT uptake scores (2: normal, 1: reduced and 0: no uptake) in basal ganglia nuclei (right and left putamina and caudate nuclei) on every scan. Striatal 123I-FP-CIT binding ratios were calculated using crescent- ROI software. The interobserver agreement for the interpretation of studies and for visual score assignment was evaluated by means of κ statistics. We investigated for associations of binding ratios with visual scores and clinical parameters; patients' clinical diagnoses served as the reference standard. Results There was excellent interobserver agreement (j 0.89-0.93) in classifying studies as "normal" or "abnormal" and fine agreement in assignment of visual scores (j 0.71-0.80 for putamina and 0.50-0.79 for caudate nuclei). Nuclei with scores of 1 and 0 showed significantly reduced binding ratios (about 30 and 50%, respectively) compared with the nuclei scored as 2. ROC analysis indicated the optimal cutoff point of striatal binding ratio at 3.8 (sensitivity 98.5%, specificity 95%) for the detection of parkinsonian syndromes. Striatal binding ratios were negatively associated with age in normal subjects and disease duration in Parkinson's disease patients. Conclusion Visual interpretation of 123I-FP-CIT studies showed very good interobserver agreement. We found significant associations among visual, semi-quantitative and clinical parameters. © The Japanese Society of Nuclear Medicine 2012
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Last time updated on 10/02/2023