Not AvailableToll-like receptor 9 (TLR9) has been characterized as a
receptor that recognizes unmethylated CpG (2'-deoxyribocytidine-phosphate-guanosine) motifs present in viral and
bacterial DNA. Evidence from both in vitro and in vivo
studies confirm that CpG-ODN can activate the immune
system in variety of domestic species including cattle, sheep,
pigs, horses, dogs, cats and chicken (Brown et al. 1998,
Kamstrup et al. 2001, Zhang et al. 2001, Mena et al. 2003,
Nichani et al. 2007). The flanking sequences in synthetic
CpG oligodeoxynucleotide (ODN) and the cellular pattern
of TLR9 expression can influence species-specific responses
to CpG-ODN (Griebel et al. 2004). The cellular pattern of
TLR9 expression and recruitment of specific cell populations
may be important factors contributing to interspecies
differences in innate and adaptive immune responses
following CpG-ODN stimulation (Griebel et al. 2005).
Proper targeting of CpG ODN for the induction of innate
immune defenses requires an understanding of immune
compartments which express high abundance of TLR9.
Buffalo is economically important animal in Asia, some
European and South American countries. It is mainstay of
dairy husbandry and contributes significantly to the milk and
meat production in India. It is pertinent to devise effective
strategies for prevention and control of buffalo diseases.
There is a little information on the differential expression of
TLR9 in buffaloes (Bubalus bubalis). Therefore, the present
study was carried out to perform quantitative analysis of
TLR9, in different immune compartments of buffalo calves.Not Availabl
