Timmis, James Kenneth

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VU Research PortalImproving healthcare innovation and decision making by extensive stakeholderinvolvementTimmis, James Kenneth2021document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)Timmis, J. K. (2021). Improving healthcare innovation and decision making by extensive stakeholderinvolvement. s.n.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 05. Nov. 2022Improving healthcare innovation and decisionmaking by extensive stakeholder involvementJames Kenneth TimmisAuthorJames Kenneth TimmisCover designFranziska JebokPrintingGildeprint (www.gildeprint.nl)© James Kenneth TimmisAll rights reserved. No part of this work may be reproduced by print, photocopy or any other meanswithout explicit and written permission of the author.ISBN: 978-94-6419-384-8VRIJE UNIVERSITEITIMPROVING HEALTHCARE INNOVATION AND DECISION MAKING BYEXTENSIVE STAKEHOLDER INVOLVEMENTACADEMISCH PROEFSCHRIFTter verkrijging van de graad Doctor of Philosophy aande Vrije Universiteit Amsterdam,op gezag van de rector magnificusprof.dr. C.M. van Praag,in het openbaar te verdedigenten overstaan van de promotiecommissievan de Faculteit der Bètawetenschappenop maandag 13 december 2021 om 15.45 uurin een bijeenkomst van de universiteit,De Boelelaan 1105doorJames Kenneth Timmisgeboren te Genève, Zwitserlandpromotor: prof.dr. H.J.H.M. Claassencopromotor: dr. L.H.M. van de Burgwalpromotiecommissie: prof.dr. J. Lamanprof.dr. H.F.J. Savelkouldr. B.J. Regeerprof.dr. A.D. Kraneveldprof.dr. K. VenemaTable of Contents1 Introduction1.1 Stakeholder inclusion in healthcare innovation . . . . . . . . . . . . . . . . . . . . . . . 101.2 Innovation theory – the bigger picture . . . . . . . . . . . . . . . . . . . . . . . . . . . 201.3 Research Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221.4 Validity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272 Core values for vaccine evaluationAbstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 302.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 312.2 Study Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 322.3 Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332.4 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 332.5 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 393 Improving accountability in vaccine decision-makingAbstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 423.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 433.2 Accountable decision-making and potentially relevant stakeholders . . . . . . . . . . . 463.3 The importance of core values for vaccine evaluation . . . . . . . . . . . . . . . . . . . 473.4 Multi-Criteria Decision Analysis and SMART vaccines . . . . . . . . . . . . . . . . . . 483.5 Transparency and accountability criteria . . . . . . . . . . . . . . . . . . . . . . . . . . 503.6 Analysis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 513.7 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 543.8 Expert commentary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 553.9 Five-year view . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 553.10 Key issues . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 564 The DIY Digital Medical CentreAbstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 584.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 594.2 Towards a solution . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 594.3 The components of the new healthcare cluster . . . . . . . . . . . . . . . . . . . . . . . 614.4 The dMC’s role in reducing inequity and costs, and increasing efficiency and quality, ofservice delivery in healthcare systems . . . . . . . . . . . . . . . . . . . . . . . . . . 654.5 The dMC-NCIC innovation and efficiency axis for integrative healthcare service evolution 674.6 Collateral benefits . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 684.7 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 695 Stakeholder Perspectives on Barriers and Facilitators for the Adoption of Virtual ClinicalTrials: Qualitative StudyAbstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 725.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 735.2 Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 745.3 Results . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 765.4 Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 825.6 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 846 Redacted (embargo)7 Redacted (embargo)8 Discussion8.1 Overview of key findings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1208.2 Subquestions per theme . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1228.3 Improving vaccine evaluation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1228.4 Facilitating personalised primary care delivery and health research . . . . . . . . . . . 1248.5 Cross-informing health innovation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1278.6 Strengths and limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1308.7 Summary and conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132Supplementary material 137References 139Summary 159List of Publications 163About the author 165Acknowledgements 167

Improving healthcare innovation and decision making by extensive stakeholder involvement

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Improving healthcare innovation and decision making by extensive stakeholder involvement

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