This chapter discusses the trend of contagion during the first wave of Covid-19 in the Marche Region, in relation to the specific demographic, socio-cultural and economic characteristics of the territory. In particular, the following aspects were taken into consideration: I) location of the main aggregative events that may have contributed to the spread of the virus, II) distribution and evolution of the infection, III) estimate of mortality attributable to the virus, IV) structure of the population by age group and aging index, V) structure of the social-health assistance system, VI) levels of NO2 and PM10 pollution, VII) production system and intra- and extra-regional commuting regimen. Results underline the significant influence of territorial and social dynamics in the spread of Covid-19 in the Marche Region
