A new membrane probing steroidal spin label: Synthesis and applications

Abstract

45-50The applicability of a new steroidal spin label, <span style="font-size:14.0pt;font-family:HiddenHorzOCR; mso-bidi-font-family:HiddenHorzOCR">3-oxo-androstan-17β-yl-(2",2",6",6"-tetramethyl-N-oxyl) piperidyl butan- 1', 4'-dioate, in studying the phase transition properties of model membrane L-α-dipalmitoyl  phosphatidyl choline (DPPC) in the presence and absence of drugs has been explored. Its synthesis and characterization has  been described, herein. Besides, the localization of this spin label in lipid liposomes has been studied using electron spin resonance (ESR), differential scanning calorimetry (DSC) and 1H and 31P NMR spectroscopic techniques. The label has also been used to study the permeability of <span style="font-size:14.0pt;font-family: HiddenHorzOCR;mso-bidi-font-family:HiddenHorzOCR">epinephrine into membrane. The results show that the spin label has a good potential as a spin probe in the study of biomembranes. </span

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