45-50The
applicability of a new steroidal spin
label, <span style="font-size:14.0pt;font-family:HiddenHorzOCR;
mso-bidi-font-family:HiddenHorzOCR">3-oxo-androstan-17β-yl-(2",2",6",6"-tetramethyl-N-oxyl)
piperidyl butan- 1', 4'-dioate, in
studying the phase transition properties of model membrane L-α-dipalmitoyl phosphatidyl choline (DPPC) in the presence
and absence of drugs has been explored. Its synthesis and characterization has been described, herein. Besides, the
localization of this spin label in lipid liposomes has been studied using
electron spin resonance (ESR), differential scanning calorimetry (DSC) and 1H
and 31P NMR spectroscopic techniques. The label has also been used
to study the permeability of <span style="font-size:14.0pt;font-family:
HiddenHorzOCR;mso-bidi-font-family:HiddenHorzOCR">epinephrine into membrane. The results show that the spin label has a
good potential as a spin
probe in the study of biomembranes.
</span