Batistatou, A.

Charalabopoulos, K.

Experimental Oncology

Наукова електронна бібліотека періодичних видань НАН України (Vernadsky National Library of Ukraine)

248	 Experimental	Oncology	28,	000–000,	2006	(June)Atypical	mitoses	are	not	unusual	in	neoplastic	cells.	They	 reflect	dysfunction	of	 chromatid	dissociation	mechanism	during	cell	division	and	possibly	represent	specific	centrosomal	alterations	involved	in	carcinogene­sis	[1–3].	It	was	shown	that	high	grade	tumors	consist	of	aneuploid	cells,	which	are	genomically	unstable	and	have	high	incidence	of	centrosome	amplification	[4].	While	genomic	instability	certainly	contributes	to	multi­step	carcinogenesis,	the	role	of	centrosome	amplifica­tion	(presence	of	more	than	two	centrosomes	during	mitosis),	as	event	contributing	in	malignant	transforma­tion	or	chromosomal	instability,	is	not	clear	at	this	time.	The	causative	relation	between	abnormal	number	of	centrosomes,	multipolar	mitoses	and	development	of	cancer	cell	was	suggested	by	Boveri	at	the	beginning	of	20th	century.	Today,	there	is	emerging	evidence	that	centrosome	aberrations	should	be	analyzed,	based	on	cellular	context	where	 they	occur,	since	 they	can	also	be	detected	in	non­malignant	cells	[4,	5].	Study	of	molecular	basis	of	normal	centrosome	duplication	and	dysfunction	of	this	process	with	oncogenic	stimuli	is	popular	field	of	modern	research.Furthermore,	neoplastic	cell	mitoses	are	back	 in	the	center	of	anti­cancer	research,	since	new	genera­tions	of	drugs	 targeting	mitosis	were	developed	[6].	Centrosomal	amplification	can	lead	to	the	assembly	of	multipolar	spindles,	which	create	spectacular	multipolar	mitotic	figures.	Herein,	we	present	a	case	of	55­year­old	man,	who	had	giant	cell	malignant	fibrous	histiocytoma	(undifferentiated	pleomorphic	sarcoma	with	giant	cells,	according	to	WHO	Classification),	in	the	retroperitoneal	region.	During	microscopic	analysis	abundant	atypical	mitoses	were	observed.	One	such	mitosis	is	depicted	in	the	Figure.	It	has	close	resemblance	to	Cross.Figure. Crossing chromosomes	in	atypical	mitosis	(hematoxylin	and	eosin	stain,	X	1000)REFERENCES1. Batistatou A. Mitoses and cancer. Med Hypotheses 2004; 63: 281–2.2. Golias Ch, Charalabopoulos A, Charalabopoulos K. Cell proliferation and cell cycle control: a mini review. Int J Clin Pract 2004; 58: 1134–41. 3. Spankuch-Schmitt B, Bereiter-Hahn J, Kaufmann M, Strebhardt K. Effect of RNA silencing of Polo-like kinase-1 (PLK-1) on apoptosis and spindle formation in human cancer cells. J Natl Cancer Inst 2002; 94: 1863–77.4. Sluder G, Nordberg J. The good, the bad and the ugly: the practical consequences of centrosome amplification. Curr Opinion Cell Biol 2004; 16: 49–54.5. Duensing S. A tentative classification of centrosome abnormalities. Cell Biol Int 2005; 29: 352–9.6. Garber K. Divide and conquer: new generation of drugs targets mitosis. J Natl Cancer Inst 2005; 97: 874–6.CRoSSiNg ChRomoSomES iN plEomoRphiC SaRComaA. Batistatou1, *, K. Charalabopoulos21Department of Pathology, University of Ioannina Medical School, Ioannina, Greece2Department of Physiology, Clinical Unit, University of Ioannina Medical School, Ioannina, GreeceReceived: March 15, 2006 *Correspondence: E-mail: abatista@cc.uoi.grExp	Oncol	200628,	3,	248Copyright © Experimental Oncology, 2006Перекрещивающиеся хромосомы в случае Плейоморфной саркомы.А. Батистату, К. Чаралабопулос

Crossing chromosomes in pleomorphic sarcoma

http://dspace.nbuv.gov.ua/xmlui/bitstream/123456789/137574/1/14-Batistatou.pdf

Crossing chromosomes in pleomorphic sarcoma

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Наукова електронна бібліотека періодичних видань НАН України (Vernadsky National Library of Ukraine)