Introduction: This Bachelors work deals with the issue of caring for patients with Gastro-Duodenal Ulcer disease. The population should be aware of the impact that the disease has which is caused by poor lifestyle and overusing of medicinal substances. The aim of the work: The aim of this work is to describe the knowledge of the patients about the regime measures moderate gastroduodenal diseases and to describe the impact of the disease on individual areas of life, Methodology: The empiric part was implemented by quantitative research through semi-structured dialog. The dialog consisted of 23 main questions and 50 subquestions. The informants above 18 years were selected from Vysočina (Highlands Region). They were 5 men and 3 women. Only two informants had medical education, the others were from the general future. The results: The obtained information was divided into four categories and eight subcategories. Through the research it was discovered that patients could be better educated about the complications of peptic ulcer disease. They showed the most knowledge in the field of nutrition and resting. The disease had the most impact on all areas of living in the most acute state. In the chronic phase of the disease, the informants did not observe a negative impact on individual areas of life. Conclusion: Healthy lifestyle is very important for prevention against peptic ulcer disease. Enough sleep, elimination of stress and regular regime can help prevent health issues. The result of this bachelors work can be a source of information for nursing students in education as well as nurses in practise. The results also point out the possible effects of the disease on individual areas of the patient's life, which should be taken into account during the treatment