Steenhoek, Adrianus

English

Nowadays for a large number of patients admitted to a hospital intravenous infusion of fluids is an important part of their treatment. These fluids serve as a correction of the fluid and/or electrolyte balance, as a carrier for drugs, as a substitute to oral nutrition or to compensate the loss of blood. Despite the fact, that many infusions are accompanied by a lot of problems, coherent and basical investigations into the origin of these problems have hardly been done. At the same time there are no criteria for the choice, judgement and use of available, sometimes very sophisticated infusion equipment. In this thesis an analysis of problems is described. It is tried to solve problems in such a way that a scheme for daily practice can be obtained. ... Zie: Summar

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   University of GroningenDrugs given by intravenous infusionSteenhoek, AdrianusIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:1983Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Steenhoek, A. (1983). Drugs given by intravenous infusion. s.n.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 20-06-2022It*- .I107SUMMARYNowadays for a large number of patients admitted to a hospital intravenous infusion of fluids is animportant part of their treatment. These fluids serve as a correction of the fluid and/or electrolytebalance, as a carrier for drugs, as a substitute to oral nutrition or to compensate the loss of blood.Despite the fact, that many infusions are accompanied by a lot of problems, coherent and basicalinvestigations into the origin of these problems have hardly been done. At the same time there areno criteria for the choice, judgement and use of available, sometimes very sophisticated infusionequipment.In this thesis an analysis of problems is described. It is tried to solve problems in such a way that ascheme for daily practice can be obtained.Hydrodynamical and pharmacokinetical principles form the basis for this study.In chapter I available data from literature are given. It follows that problems are described atrandom and without connection. The chapter is concluded by the description ofthe direct reasonto do the study.In chapter II it is described how to control infusion rates based on hydrodynamical principles.Apart from system dependent variables, physical properties and patient dependent variables arethe main factors for fluctuations in infusion rates.An in vitro study, based on calculations as presented in chapter II, is described in chapter III.Electronical and disposable infusion rate controllers are studied extensively.Besides, costs connected to the use ofthese controllers, are calculated and recommendations aredone.Chapter III describes also the study of drop counting in the counting chamber of the infusionsystem to control the infusion rate.Main factors which influence drop volume and the connecting infusion rate are studied. Rules aregiven for daily practice. They show very clearly the necessity of an extensive standardization ofthe entire infusion process.In chapter IV the magnitude of fluctuations in the blood level of a drug due to variations in theinfusion rate is described.The halÊlife and the therapeutic margin of the used drug are important parameters. Besides, theaccuracy of infusion rate controllers is calculated.In chapter V problems connected with parenteral nutrition are described.These problems have their own place, as a result of the very different physical properties of theused infusion fluids when compared to normal fluids.A scheme for infusion rate control based on theoretical considerations and in vitro studies is testedin daily practice with the aid of some model substances.The results are described in chapter VI and VII.Chapter VI presents the results of an in vivo study with disposable infusion rate controllers usingaminophylline as a model substance for drugs with a long half-life (>1h).In addition, this study has provided a good deal of information aboutthe model substance itself. Itis concluded that the infusion of aminophylline has generally speaking no further role to play asmaintenance dose.In this study the disposable infusion rate controllers satisfy very well.In chapter VII the results of a study with two betar-sympathomimetics used for the inhibition ofpreterm labor is described.Fenoterol serves as a model substance for drugs with a short half-life (<lh).It is compared with ritodrine to study the influence of different pharmacokinetical parameters onclinical effect.Chapter VIII describes some new developments.Finally, in chapter IX conclusions ofthe theoretical considerations, in vitro and in vivo studies aredescribed.ts*II|!"'ry'1.--F"".*l*rtIi-[

Drugs given by intravenous infusion

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Drugs given by intravenous infusion

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