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Medical management of gastric cancer: a 2017 update
Authors
Economopoulou P., Kotsantis I., Tolia M., Schizas D., Liakakos T., Elimova E., Ajani J.A., Psyrri A. Charalampakis N.
Publication date
1 January 2018
Publisher
'Wiley'
Doi
Cite
Abstract
Gastric cancer remains a considerable health burden throughout the world. The Cancer Genome Atlas (TCGA) analysis has recently unveiled 4 genotypes of gastric cancer with data not ready to change treatment strategy yet. A multimodality approach to therapy is the cornerstone of screening, diagnosing, staging, treating and supporting patients with gastric cancer. The evidence-based approach to localized gastric cancer (>cT1b) is to use an either preoperative or postoperative strategy to maximize the benefit of surgery. The focus of future research is to optimize chemotherapy regimens, determine the role of radiation therapy and investigate the effect of treatment timing. In metastatic gastric cancer, biologic therapies have been introduced targeting markers shown to be prognostic. The results of ongoing randomized controlled phase 3 trials using targeted and immunotherapy agents, either in combination or alone, have the potential to alter the current treatment landscape of advanced gastric cancer. © 2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd
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University of Thessaly Institutional Repository
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oai:ir.lib.uth.gr:11615/72519
Last time updated on 13/02/2023
Pergamos : Unified Institutional Repository / Digital Library Platform of the National and Kapodistrian University of Athens
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oai:lib.uoa.gr:uoadl:3085569
Last time updated on 10/02/2023