Boermans, J. A. J.

Tuerlings, J. H. A. M.

Tuinier, S.

van Ravenswaay-Arts, C M A

Verhoeven, W. M. A.

Background and Objectives: In clinical psychiatry genetic anomalies are infrequently part of the differential diagnosis, especially in the elderly. Two case reports are used to illustrate the relevance of a genetic workup for diagnosis, treatment and prognosis.Methods: A female and a male patient, aged 8 1 and 68 year respectively, were admitted because of psychotic symptoms. Despite their relatively low level of intelligence together with autistic-like behaviour in the female patient and dysmorphias in the male patient, a genetic disorder was previously never considered.Results: In the female patient a balanced translocation between chromosomes X and 19 was found, while in the male patient a mosaic trisomy 8 was demonstrated.Conclusions: Genetic analysis is indicated in patients with autism, lower intelligence, unexplained somatic anomalies and dysmorphias.</p

Chromosomal abnormalities in clinical psychiatry:a report of two older patients

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Proceedings - University of Groningen