Dijck-Brouwer, D. A. J.

Muskiet, F. A. J.

Schaafsma, A.

Stoutjesdijk, E.

English

Background: Iodine deficiency occurs in West European countries. Iodine is important for brain development of the foetus and infant. The current iodine status of pregnant and lactating Dutch women is unknown.Methods: In a pilot study we examined the iodine status of 36 women. From 20 gestational weeks (GW) until 4 weeks postpartum, they ingested 150 mu g iodine/day in the form of a multivitamin supplement for pregnant and lactating women. Twenty-four hour urine samples were collected at 20 and 36 GW and at 4 weeks postpartum. A breast milk sample was collected at 4 weeks postpartum. Iodine concentrations were analysed by inductively coupled plasma-mass spectrometry. Cut-off values for the urinary iodine concentration (UIC) for pregnant and lactating women are 150 and 100 mu g/l, respectively. Adequate intakes (AI) of iodine for infants aged 0-6 months are 1.1 mu mol/l (Institute of Medicine recommendations) or 0.5 mu mol/l (Nordic Council recommendations).Results: The median UICs (percentages below cut-off) were 102 mu g/l (83%) at 20 GW, 144 mu g/l (56%) at 36 GW and 112 mu g/l (40%) at 4 weeks postpartum. The median breast milk iodine concentration was 1.2 mu mol/l (range 0.5-3.0); 33% and 0% of the infants had estimated iodine intakes below the IOM-AI and Nordic-AI, respectively.Conclusion: This pilot study suggested a high prevalence of iodine deficiency during pregnancy. Daily supplementation of 150 mu g iodine from 20 GW might be insufficient to reach maternal iodine adequacy. The median breast milk iodine concentration seems adequate. Further studies, using a representative sample of the Dutch population, are needed to establish the current Dutch iodine status of pregnant and lactating women.</p

ARTS repository - University of Groningen

Iodine status during pregnancy and lactation:a pilot study in the Netherlands

https://pure.rug.nl/ws/files/75713121/getpdf_1_.pdf

Iodine status during pregnancy and lactation:a pilot study in the Netherlands

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ARTS repository - University of Groningen