Galli, Filippo

English

The events that drive tumor progression and metastatization initiate within the cancer cell itself, that accumulates mutations and de-differentiate until reaching a very unstable stage. But these events alone are not sufficient to maintain sustained metastasis development and growth. Support from the host is required in order to promote angiogenesis and inhibit immune response that would kill cancer cells. The sum of these events is the result of the interaction between the tumor and cellular or non-cellular components that surround the cancer cells. This concept gained more and more importance during the recent years due to the possibility to develop a wide range of therapeutic strategies to target those components and pathways involved in the establishment of tumor microenvironment. However, it has been reported that cancer lesions, even within the same patient, may express different markers, thus, needing two different therapeutic approaches. Therefore, there is the need of a non-invasive tool to characterize each lesion before planning the most appropriate therapy. This will allow to save money, time and reduce the side-effects as much as possible. In this scenario, nuclear medicine offers a wide set of potential radiopharmaceuticals to image markers expressed by both cancer cells and microenvironment allowing to plan the most appropriate therapy in each patient. In this thesis we present four different strategies to image tumor specific antigens and microenvironment focusing on cancer, immune system and angiogenesis

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   University of GroningenImaging of tumor specific antigens and microenvironmentGalli, FilippoIMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite fromit. Please check the document version below.Document VersionPublisher's PDF, also known as Version of recordPublication date:2015Link to publication in University of Groningen/UMCG research databaseCitation for published version (APA):Galli, F. (2015). Imaging of tumor specific antigens and microenvironment. [Thesis fully internal (DIV),University of Groningen]. University of Groningen.CopyrightOther than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of theauthor(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license.More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne-amendment.Take-down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons thenumber of authors shown on this cover page is limited to 10 maximum.Download date: 13-02-2023Propositions  1. Radiopharmaceuticals that target markers of tumor microenvironment allow us to perform in vivo molecular characterization of lesions (this thesis, chapter 1).  2. Scintigraphy with radiolabelled rhTSH superagonists can image both NIS+ and NIS- metastases from thyroid carcinoma, and might be used for pre-operative staging as well as for long term follow-up of patients (this thesis, chapter 2).  3. Radiolabelled Infliximab is an useful tool to evaluate the presence of TNFα in solid lesion and helps in planning immunotherapies in sarcoidosis (this thesis, chapter 3).  4. Natural killer cells are the major cell type involved in killing cancer cells. In vivo imaging of NK cells allows to monitor their infiltration in tumors and metastases in response to various immunotherapeutic approaches, thus, opening new doors to personalized immunotherapy (this thesis, chapter 4).  5. An important feature of microenvironment is the expression of VEGFR and VEGF. The possibility to detect them in vivo by scintigraphy with radiolabelled VEGF-165 or anti-VEGFR mAb, is a valid tool for planning adjuvant therapy in cancer patients  (this thesis, chapter 5).  6. Science is organized knowledge. Wisdom is organized life (Immanuel Kant 1724 - 1804).  7. There are no inexplicable things, but only unintelligible ones.  8.  In scientific research there are no good or bad results. There are positive and negative ones, which, often, are equally important.  9. Growth is always the result of a stimulating microenvironment, both biologically and professionally speaking.  10. It is not true that we do not have time to do everything we would like to. The truth is that sometimes we do not use our time wisely.   

Imaging of tumor specific antigens and microenvironment

https://pure.rug.nl/ws/files/24174909/Propositions.pdf

Imaging of tumor specific antigens and microenvironment

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