Alves, Paulo

Baptista-Silva, Sara

Bonifácio, Graça

Madureira, Sara

Oliveira, Ana L.

Sousa, Miguel

Vilaça, Helena

English

Repositório Institucional da Universidade Católica Portuguesa

Regarding the additives, our research isfocused on natural based bioactivesubstances, such as plant extracts (in theliquid and powder form) and oils.These substances possess a wide range ofproperties, from antimicrobial, antioxidantand anti-inflammatory activity, tomoisturizing and regenerative capacity.1 Universidade Católica Portuguesa, CBQF - Centro de Biotecnologia e Química Fina – Laboratório Associado, Escola Superior de Biotecnologia, Porto, Portugal;2 Universidade Católica Portuguesa , Centro de Investigação Interdisciplinar em Saúde, Instituto de Ciências da Saúde, Porto, Portugal;3 CITEVE, Centro Tecnológico das Indústrias Têxtil e do Vestuário de Portugal, V. N. Famalicão, Portugal;4 SOMANI, Sociedade Têxtil S.A., Salvador do Campo, Portugal;*aloliveira@ucp.ptTEX4WOUNDS – Development of advanced textile materials for wound careSara Madureira1, Sara Baptista-Silva1, Paulo Alves2, Helena Vilaça3, Graça Bonifácio3, Miguel Sousa4, Ana L. Oliveira1*Introduction/Resume ObjectivesDevelopmentAcknowledgementsThe main goal of this project is the development of a range of products, basedon new textile architectures, for the cleaning and the treatment of wounds.The novel textile structures will be produced by terry-weave knitting, and willinclude functional fibers. The structures will also be impregnated with naturalbioactive additives with relevant properties for wound care.To this end, 2 groups of devices will be developed:1) A dressing material for cleaning and debridement with two distinct faces - asofter one (with possibly an additive) and a rougher one (for mechanicdebridement);2) A dynamic, multilayered, absorbent and healing-promoting dressingmaterial - It will be developed in two concepts, according to the type of wound:a) Laminated structure dressing: for superficial and shallow wounds with anaverage high amount of exudate;b) Core structure dressing: for deep, local wounds with a medium to highamount of exudate.Different textile structures have been produced, with distinct architectures,grammages and fiber combinations. These samples suffered four processingsteps: (1) washing, (2) autoclave, (3) half-bleaching, (4) half-bleaching followed byautoclave.All samples were characterized at all processing steps, regarding their interactionwith fluids: fluid absorption capacity, fluid retention capacity, wicking and theirwater vapor permeability. This allowed us to understand the effect of theprocessing steps on the textiles characteristics and properties. All theseparameters need to be taken into consideration when choosing the textiles thatwill be used in the production of the dressing materials. The textile fibers werealso observed by Scanning Electron Microscopy, SEM (Figure 1).This work was supported by the project “TEX4WOUNDS - Development of advanced textile materials for wound care” (nº POCI-01-0247-FEDER-047029), financed under theIncentive System for Research and Technological Development, R&DT Projects in co-promotion (Notice 17/SI/2019), to be developed by the company SOMANI in co-promotion with the non-business entities of the CITEVE R&I System and the Center for Biotechnology and Fine Chemistry (Associated Laboratory) of the Escola Superior deBiotecnologia do Porto from the Portuguese Catholic University and with the company FOURMAG.Wounds can be described as interruptions of the continuity of a tissue,caused by any type of physical, chemical, or mechanical trauma, or triggeredby a medical condition.Taking into account the context and the social and economic impact ofwounds on patients, caregivers and health systems, as well as thetechnological evolution, cost, constraints and difficulties in using dressingmaterials, the TEX4WOUNDS consortium intends to develop a range ofadvanced devices to provide an effective and cost-effective wound careresponse.Textiles combine characteristics that constitute great advantages in thedevelopment of new dressing products, such as strength, extensibility,flexibility, air and moisture permeability, high surface area and highabsorption capacity. Moreover, they are highly tunable: can be produced intothree-dimensional structures, using a great variety of fibers (or filaments) andin any shape and geometry. Also, textiles provide the possibility offunctionalization by different techniques and with many bioactive molecules.Figure 1. Representative images of textile samples acquired by SEM.Studies with the interest extracts are already in motion. Different encapsulationmethods are being tested and the resulting capsules are being impregnated ontothe textiles, using several impregnation methods.Next steps will focus on studying the release profiles of the encapsulatedbiomolecules, considering varying external factors such as pH, temperature and ,moisture levels.The choice of the right additives for each material, as well as the concentrationto be used in the final product will rely on the above mentioned tests, as well asthe biocompatibility assays that will be performed using Human DermalFibroblasts (HDF’s).

TEX4WOUNDS: development of advanced textile materials for wound care

https://repositorio.ucp.pt/bitstream/10400.14/40030/1/CBQF_Tex4Wounds_Development_of_AdvancedTextileMaterials_for_WoundCare_Sara_Madureira.pdf

TEX4WOUNDS: development of advanced textile materials for wound care

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