Helminth infections are an important health problem for both humans and animals worldwide. The most sought for prophylactic strategy is vaccination due to the increasing incidence of anthelminthic resistance with little progress towards the discovery of novel drugs. However, the development of efficient anti-parasitic vaccines was proven to be a far greater challenge than in the case of bacteria or viruses. This is partly a result of the complex immunological interactions occurring during helminth infections, which are not yet fully understood, especially regarding the immune mechanisms conveying protection. Another problem is progressing from the research phase of vaccine development to commercial production and marketing. The advances made so far in developing efficient vaccines against helminth vary among the different classes, with a wide spectrum of both native and recombinant vaccine candidates. This review aims at presenting the current status and most important achievements in the field of helminth vaccine development, as well as the main obstacles and difficulties standing in the way of progress and practical applications
