Hypolipidemic activity of ethyl acetate fraction of methanolic seed extract of Persia Americana mill (Lauraceae) in rats

Abstract

Parts of Persea americana Mill are used for various ethnomedicinal purposes. The aqueous seed extract is used locally by herbalists for the treatment of hyperlipidemia. In this study, our objective was to investigate the possible hypolipidemic effect of ethyl acetate fraction (EAF) of the methanolic seed extract on olive oil- induced hyperlipidemia in rats. Oral administration of olive oil (5 ml/kg) resulted in the elevation of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLC) and glucose and reduction in high density lipoprotein cholesterol (HDLC). However, acute treatment with various doses of EAF of the methanolic seed extract of P. americana caused a significant (PPersea americana seed showed hypolipidemic effect and may serve as possible alternative treatment for hyperlipidemia.Keywords: Total cholesterol; triglycerides; high density lipoprotein; low density lipoprotein; olive oil; arterogenic index of plasmaJournal of Pharmaceutical and Allied Sciences, Vol. 10 No. 3 (2013